People with Alzheimer’s disease who were treated with diabetes drugs showed considerably fewer symptoms, Mount Sinai researchers have found.

This first-ever study examined what happens in the pathways of both brain tissue and endothelial cells — the cells lining blood vessels — in the brains of Alzheimer’s patients.

“The results of this study are important because they give us new insights for the treatment of Alzheimer’s disease,” said Vahram Haroutunian, Ph.D., a professor of psychiatry and neuroscience at Mount Sinai.

“This opens opportunities to conduct research trials on people using similar drugs or on drugs that have similar effects on the brains’ biological pathways and cell types identified in this study,” he added.

These findings help guide future investigations and lead to new therapeutic interventions, Haroutunian said.